Aqueous and ethanol extracts of Cassiae semen have been reported to consistently reduced arterial blood pressure, by inhibiting receptor-controlled calcium channels on vessels and regulating the secretion of nitric oxide and inducible nitric oxide synthase.
Modern pharmacological studies demonstrated that Apocynum venetum possess wide pharmacological activities that include antihypertensive, cardiotonic, hepatoprotective, antioxidant, lipid-lowering, antidepressant and anxiolytic effects, which can be explained by the presence of various flavonoid compounds in this plant.
The significant antihypertensive effect of GEBE is achieved by inhibiting the endothelin-converting enzyme and via its antioxidant activity.
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